Article
Deciphering the role of platelets in severe allergy by an integrative omics approach.
Allergy - 1 May 2023
Pablo-Torres Carmela, Izquierdo Elena, Tan Tiak Ju, Obeso David, Layhadi Janice A, Sánchez-Solares Javier, Mera-Berriatua Leticia, Bueno-Cabrera José Luis, Del Mar Reaño-Martos María, Iglesias-Cadarso Alfredo, Barbas Coral, Gomez-Casado Cristina, Villaseñor Alma, Barber Domingo, Shamji Mohamed H, Escribese María M
Abstract excerpt
BACKGROUND: Mechanisms causing the onset and perpetuation of inflammation in severe allergic patients remain unknown. Our previous studies suggested that severe allergic inflammation is linked to platelet dysfunction. METHODS: Platelet-rich plasma (PRP) and platelet-poor plasma (PPP) samples were obtained by platelet-apheresis from severe (n = 7) and mild (n = 10) allergic patients and nonallergic subjects...
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