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Article

Combination scRNA-seq with GWAS identifies genetic risk factors in IgA nephropathy: An observational study.

Medicine - 15 May 2026

Zhang Jinhua, Lu Shuo, Liang Guancan, Wang Ruojiao, Zhou Hui, Na Ning, Liu Mingjing, Zhong Zhaozhong

Abstract excerpt

IgA nephropathy (IgAN) is a common autoimmune kidney disease and a leading cause of chronic kidney disease (CKD), yet the immune cell-specific mechanisms underlying disease progression remain incompletely understood, particularly with respect to macrophage heterogeneity. We analyzed single-cell RNA sequencing (scRNA-seq) data from IgAN and CKD kidney samples to characterize macrophage subpopulations and identify...

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Share to Glomerulonephritis, IGA
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Renal Insufficiency, Chronic

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Source

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Identifiers

PMID: 42152401
DOI: 10.1097/MD.0000000000048751
PMCID: PMC13183021

Genes

RGS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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