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Immune cell signatures and inflammatory mediators: unraveling their genetic impact on chronic kidney disease through Mendelian randomization.

Clinical and experimental medicine - 4 May 2024

Hu Yongzheng, Hao Fengyun, An Qian, Jiang Wei

Abstract excerpt

Prior research has established associations between immune cells, inflammatory proteins, and chronic kidney disease (CKD). Our Mendelian randomization study aims to elucidate the genetic causal relationships among these factors and CKD. We applied Mendelian randomization using genetic variants associated with CKD from a large genome-wide association study (GWAS) and inflammatory markers from a comprehensive GWAS...

Topics

Humans
Mendelian Randomization Analysis
Renal Insufficiency, Chronic
Genome-Wide Association Study
Inflammation Mediators
Genetic Predisposition to Disease

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 38703294
DOI: 10.1007/s10238-024-01341-z
PMCID: PMC11069478

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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