Article
Telomere-driven mutational processes in yeast.
Current opinion in genetics & development - 1 Feb 2020
Henninger Erin, Teixeira Maria T
Abstract excerpt
Telomeres are part of the system that guards genome integrity in eukaryotes, protecting linear chromosomes from fusions and degradations. The protective functions of telomeres are put at risk in physiological situations where telomeres shorten and trigger replicative senescence. Current models suggest that when telomeres shorten, combined actions of the DNA damage signalling network, DNA repair pathways, and the...
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