Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Update and reuse: Structure-guided nanobody evolution against SARS-CoV-2 escape.

PLoS pathogens - 1 May 2026

Bu Fan, Saxena Divyasha, Turner-Hubbard Hailey, Delaney Amy, Batra Lalit, Fricke Charlie, Moye Skyler, Verma Abhishek, Perlman Stanley, Bhandari Janarjan, Liu Bin, Ye Gang, Zheng Jian, Li Fang

Abstract excerpt

SARS-CoV-2 continues to accumulate spike mutations that erode the efficacy of antibody therapeutics. The Q493E mutation in the spike RBD, present in recent Omicron subvariants, enables escape from many antibodies and nanobodies, including our Nanosota-9A nanobody, which neutralizes Omicron JN.1 (Q493) but not KP.3 (E493). To address this, we applied a structure-guided in vitro evolution strategy to engineer...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Neutralizing
Share to Antibodies, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to COVID-19

Share to Directed Molecular Evolution

Share to Mutation

Share to SARS-CoV-2

Share to Single-Domain Antibodies

Share to Spike Glycoprotein, Coronavirus

Source

Open in PubMed Open full text

Identifiers

PMID: 42149970
DOI: 10.1371/journal.ppat.1014223
PMCID: PMC13193604

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Update and reuse: Structure-guided nanobody evolution against SARS-CoV-2 escape.PMID 42149970Read ↗

Highly synergistic combinations of nanobodies that target SARS-CoV-2 and are resistant to escapeSemantic proximity Read ↗

Structure-guided in vitro evolution of nanobodies targeting new viral variants.Semantic proximity Read ↗

Nanobody repertoire generated against the spike protein of ancestral SARS-CoV-2 remains efficacious against the rapidly evolving virusSemantic proximity Read ↗

Nanobody Repertoires for Exposing Vulnerabilities of SARS-CoV-2Semantic proximity Read ↗

Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape.Semantic proximity Read ↗

Biparatopic sybodies neutralize SARS‐CoV‐2 variants of concern and mitigate drug resistanceSemantic proximity Read ↗

Versatile, Multivalent Nanobody Cocktails Efficiently Neutralize SARS-CoV-2Semantic proximity Read ↗

A bivalent spike-targeting nanobody with anti-sarbecovirus activitySemantic proximity Read ↗

Neutralization of SARS-CoV-2 by highly potent, hyperthermostable, and mutation-tolerant nanobodies.Semantic proximity Read ↗

A panel of nanobodies recognizing conserved hidden clefts of all SARS-CoV-2 spike variants including OmicronSemantic proximity Read ↗

Biparatopic sybody constructs neutralize SARS-CoV-2 variants of concern and mitigate emergence of drug resistanceSemantic proximity Read ↗

An ultrapotent RBD-targeted biparatopic nanobody neutralizes broad SARS-CoV-2 variantsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.