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Article

Clinical proteome informatics workbench detects pathogenic mutations in hereditary amyloidoses.

Journal of proteome research - 2 May 2014

Dasari Surendra, Theis Jason D, Vrana Julie A, Zenka Roman M, Zimmermann Michael T, Kocher Jean-Pierre A, Highsmith W Edward, Kurtin Paul J, Dogan Ahmet

Abstract excerpt

Shotgun proteomics of hereditary amyloid deposits generates all the information necessary to identify pathogenic mutant peptides and proteins. However, these mutant peptides are invisible to traditional database search strategies. We developed a two-pronged informatics workflow for detecting both...

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PMID: 24650283
DOI: 10.1021/pr4011475

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24650283-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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