Article
Exome Sequencing with Validations and Expression of p16/CDKN2A Shows no Association with HPV in Oral Cancers.
Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2022
Shyamsundar Vidyarani, Thangaraj Soundara Viveka, Krishnamurthy Arvind, Vimal Sanjana, Kesavan Pallavi, Babu Aravinda, Kmk Masthan, Ramshankar Vijayalakshmi
Abstract excerpt
PURPOSE: Despite many studies attributing HPV infection to oropharyngeal tumorigenesis, its involvement in non-oropharyngeal cancers is ambiguous. We have evaluated the mutation profile of p16 along with protein expression and correlated it with the HPV status in oral cancers. METHODS: Somatic mutations in p16 were studied by exome sequencing (n=25) and validated by Sequenom Mass spectrometry (n=50). Expression...
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