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Article

Genetic variation within the human papillomavirus type 16 genome is associated with oropharyngeal cancer prognosis.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Jun 2022

Lang Kuhs K A, Faden D L, Chen L, Smith D K, Pinheiro M, Wood C B, Davis S, Yeager M, Boland J F, Cullen M, Steinberg M, Bass S, Wang X, Liu P, Mehrad M, Tucker T, Lewis J S, Ferris R L, Mirabello L

Abstract excerpt

PURPOSE: A significant barrier to adoption of de-escalated treatment protocols for human papillomavirus-driven oropharyngeal cancer (HPV-OPC) is that few predictors of poor prognosis exist. We conducted the first large whole-genome sequencing (WGS) study to characterize the genetic variation of the HPV type 16 (HPV16) genome and to evaluate its association with HPV-OPC patient survival. PATIENTS AND METHODS: A...

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Identifiers

PMID: 35306154
DOI: 10.1016/j.annonc.2022.03.005
PMCID: PMC9350957

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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