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Lymph node metastasis in oral cancer is strongly associated with chromosomal instability and DNA repair defects

29 Mar 2019

Abstract excerpt

Oral squamous cell carcinoma (OSCC) is highly prevalent in south and southeast Asia. Many (30-50%) OSCC patients develop lymph node metastasis (LNM), which is the most important prognostic factor in OSCC. To identify genomic correlates of LNM, we compared exome sequences and copy number variation data of blood and tumor DNA from highly contrasting subgroups of patients to reduce false inferences-(i) patients with...

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PMID: 30924133
DOI: 10.1002/ijc.32305

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