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Article

Exome Sequencing Identifies Potentially Druggable Mutations in Nasopharyngeal Carcinoma.

Scientific reports - 3 Mar 2017

Chow Yock Ping, Tan Lu Ping, Chai San Jiun, Abdul Aziz Norazlin, Choo Siew Woh, Lim Paul Vey Hong, Pathmanathan Rajadurai, Mohd Kornain Noor Kaslina, Lum Chee Lun, Pua Kin Choo, Yap Yoke Yeow, Tan Tee Yong, Teo Soo Hwang, Khoo Alan Soo-Beng, Patel Vyomesh

Abstract excerpt

In this study, we first performed whole exome sequencing of DNA from 10 untreated and clinically annotated fresh frozen nasopharyngeal carcinoma (NPC) biopsies and matched bloods to identify somatically mutated genes that may be amenable to targeted therapeutic strategies. We identified a total of 323 mutations which were either non-synonymous (n = 238) or synonymous (n = 85). Furthermore, our analysis revealed...

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Identifiers

PMID: 28256603
DOI: 10.1038/srep42980
PMCID: PMC5335658

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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