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Pan-Cancer Comparative and Integrative Analyses of Driver Alterations Using Japanese and International Genomic Databases.

Cancer discovery - 1 May 2024

Horie Sara, Saito Yuki, Kogure Yasunori, Mizuno Kota, Ito Yuta, Tabata Mariko, Kanai Takanori, Murakami Koichi, Koya Junji, Kataoka Keisuke

Abstract excerpt

Using 48,627 samples from the Center for Cancer Genomics and Advanced Therapeutics (C-CAT), we present a pan-cancer landscape of driver alterations and their clinical actionability in Japanese patients. Comparison with White patients in Genomics Evidence Neoplasia Information Exchange (GENIE) demonstrates high TP53 mutation frequencies in Asian patients across multiple cancer types. Integration of C-CAT, GENIE,...

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Source

Identifiers

PMID: 38276885
DOI: 10.1158/2159-8290.CD-23-0902

Genes

CAT
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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