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Article

Pathogenesis of immunoglobulin A nephropathy: recent insight from genetic studies.

Annual review of medicine - 1 Jan 2013

Kiryluk Krzysztof, Novak Jan, Gharavi Ali G

Abstract excerpt

Recent genome-wide association studies (GWAS) have identified multiple susceptibility loci for immunoglobulin A nephropathy (IgAN), the most common form of glomerulonephritis, implicating independent defects in adaptive immunity (three loci on chromosome 6p21 in the MHC region), innate immunity (8p23 DEFA locus, 17p23 TNFSF13 locus, 22q12 HORMAD2 locus), and the alternative complement pathway (1q32 CFH/CFHR...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23072577
DOI: 10.1146/annurev-med-041811-142014
PMCID: PMC3921622

Genes

CFH
HORMAD2
TNFSF13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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