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Article

Complement Factor I Variants in Complement-Mediated Renal Diseases.

Frontiers in immunology - 1 Jan 2022

Zhang Yuzhou, Goodfellow Renee X, Ghiringhelli Borsa Nicolo, Dunlop Hannah C, Presti Stephen A, Meyer Nicole C, Shao Dingwu, Roberts Sarah M, Jones Michael B, Pitcher Gabriella R, Taylor Amanda O, Nester Carla M, Smith Richard J H

Abstract excerpt

C3 glomerulopathy (C3G) and atypical hemolytic uremic syndrome (aHUS) are two rare diseases caused by dysregulated activity of the alternative pathway of complement secondary to the presence of genetic and/or acquired factors. Complement factor I (FI) is a serine protease that downregulates complement activity in the fluid phase and/or on cell surfaces in conjunction with one of its cofactors, factor H (FH),...

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Identifiers

PMID: 35619721
DOI: 10.3389/fimmu.2022.866330
PMCID: PMC9127439

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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