Article

Combining chemogenomic and gene-dose assays to investigate drug synergy

2021-02-02

Abstract excerpt

From the earliest days of using natural remedies to modern applications of clinically tested medications, combining therapies for disease treatment has been standard practice. Combination treatments can exhibit synergistic effects, broadly defined as a greater-than-additive effect of two or more therapeutic agents. Indeed, clinicians often use their experience and expertise to tailor such combinations in the hopes...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cbaf2da5-9f40-56ff-915a-0215841fabc4
DOI: 10.1101/2021.02.01.429253

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Combining chemogenomic and gene-dose assays to investigate drug synergyDOI 10.1101/2021.02.01.429253Read

Systematic discovery of drug interaction mechanisms.Semantic proximity Read

High-throughput identification and rational design of synergistic small-molecule pairs for combating and bypassing antibiotic resistance.Semantic proximity Read

Defining principles of combination drug mechanisms of action.Semantic proximity Read

Systems-level antimicrobial drug and drug synergy discovery.Semantic proximity Read

A curative combination cancer therapy achieves high fractional cell killing through low cross-resistance and drug additivity.Semantic proximity Read

metascreen: A modular tool for the design and analysis of drug combination screensSemantic proximity Read

Novel Synergies and Isolate Specificities in the Drug Interaction Landscape of Mycobacterium abscessusSemantic proximity Read

A statistical framework for defining synergistic anticancer drug interactionsSemantic proximity Read

Large scale phage-antibiotic combination studies reveal key combinations for urinary tract infection and urosepsis treatmentsSemantic proximity Read

Transcriptomic signatures predict regulators of drug synergy and clinical regimen efficacy against TuberculosisSemantic proximity Read

Strain diversity drives heterogeneous responses to tuberculosis combination therapySemantic proximity Read

Systematic measurement of combination drug landscapes to predict <i>in vivo</i> treatment outcomes for tuberculosisSemantic proximity Read