Article
On the genetic origins of phenotypes in genome-wide association studies: the SAFE-h2 tool for exploring additive and non-additive allelic effects.
BMC bioinformatics - 14 May 2026
Darbani Behrooz, Nicolaisen Mogens
Abstract excerpt
BACKGROUND: This study highlights biologically meaningless negative contributions to heritability estimates and introduces SAFE-h2 method and application tool for accurate genetic estimates in genome-wide association studies. RESULTS: By examining 74 phenotypes across eight species, SAFE-h2 revealed an average negative contribution, i.e., downward bias, of 30 units to SNP heritability estimates. Furthermore,...
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