Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HPV-Associated Sarcomatoid (Spindle Cell) Carcinoma of the Base of the Tongue with HRAS and TERT Promoter Mutations.

Head and neck pathology - 14 May 2026

Durham Lacey, Jennings Lawrence J, Patil Yash J, Alexiev Borislav A

Abstract excerpt

BACKGROUND: Sarcomatoid carcinoma is an aggressive and uncommon variant of squamous cell carcinoma that is rarely encountered in the oropharynx. Distinguishing this entity from true sarcomas or reactive stromal proliferations can be challenging, particularly in cases where the conventional squamous component is minimal or not readily apparent. Molecular characterization of head and neck sarcomatoid carcinomas...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Squamous Cell
Share to Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Papillomavirus Infections

Share to Promoter Regions, Genetic

Share to Proto-Oncogene Proteins p21(ras)

Share to Squamous Cell Carcinoma of Head and Neck

Share to Telomerase

Share to Tongue Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 42133216
DOI: 10.1007/s12105-026-01922-2
PMCID: PMC13176429

Genes

HRAS
TERT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HPV-Associated Sarcomatoid (Spindle Cell) Carcinoma of the Base of the Tongue with HRAS and TERT Promoter Mutations.PMID 42133216Read ↗

Uncommon and Challenging Phenotypes of High-Risk Human Papillomavirus-Associated Head and Neck Carcinomas Revealed by High-Throughput Studies.Semantic proximity Read ↗

Squamous cell carcinoma variants of the upper aerodigestive tract: a comprehensive review with a focus on genetic alterations.Semantic proximity Read ↗

Case Report: Basaloid Squamous Cell Carcinoma of the Tongue: A Case ReportSemantic proximity Read ↗

Biphasic Synovial Sarcoma of the Hypopharynx in a Six-Year-Old Child Diagnosed via SS18 Immunohistochemistry Without Molecular Confirmation in a Resource-Limited Setting: A Case ReportSemantic proximity Read ↗

A high-grade sarcoma with TRIM25::NTRK2 rearrangements in the head and neck: case reportSemantic proximity Read ↗

Histiocytic sarcoma affecting the oral cavity: a clinical, pathologic and molecular study.Semantic proximity Read ↗

Apocrine epithelial-myoepithelial carcinoma with phyllodes-like morphology of the parotid gland: A case report of an unusual histology with immunohistochemical and genetic analyses using next-generation sequencingSemantic proximity Read ↗

Head and neck squamous cell carcinomas of unknown primary: Can ancillary studies help identify more primary tumor sites?Semantic proximity Read ↗

TERTp mutations and p53 expression in head and neck cutaneous basal cell carcinomas with different aggressive features.Semantic proximity Read ↗

Mucoepidermoid carcinoma of the base of tongue:A case report and literature reviewSemantic proximity Read ↗

Spindle cell carcinoma of head and neck: an immunohistochemical and molecular approach to its pathogenesis.Semantic proximity Read ↗

Oncogenic Human Papillomaviruses Drive One-Third of Sinonasal Squamous Cell Carcinoma and Are Not Mutually Exclusive for Gene Mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.