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Head and neck squamous cell carcinomas of unknown primary: Can ancillary studies help identify more primary tumor sites?

Experimental and molecular pathology - 1 Aug 2024

Hutchens Troy, Thorstad Wade, Wang Xiaowei, Li Yuanxiang, Duncavage Eric J, Sun Lulu, Chernock Rebecca D

Abstract excerpt

A subset of head and neck squamous cell carcinomas present solely as metastatic disease in the neck and are of unknown primary origin (SCCUP). Most primary tumors will ultimately be identified, usually in the oropharynx. In a minority of cases, the primary site remains elusive. Here, we examine the role of ancillary testing, including mutational signature analysis (MSA), to help identify likely primary sites in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38964052
DOI: 10.1016/j.yexmp.2024.104915
PMCID: PMC11458069

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