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Article

TERTp mutations and p53 expression in head and neck cutaneous basal cell carcinomas with different aggressive features.

Scientific reports - 17 May 2021

Castanheira António, Vieira Maria João, Pinto Mafalda, Dias Carolina, Prada Luísa, Macedo Sofia, Fernandes Margarida Sá, Vieira Fortunato, Soares Paula, Mota Alberto, Lopes José Manuel, Boaventura Paula

Abstract excerpt

Cutaneous basal cell carcinoma (cBCC) is an economic burden to health services, due to its great morbidity and increasing incidence in old people. Infiltrative cBCCs and cBCCs with micronodular pattern are considered as more aggressive. The role of p53 expression and TERTp mutation on cBCC behavior remains to be clarified. We aimed to assess TERTp mutations and p53 expression in relation to the cBCC histological...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Neoplastic

Share to Head and Neck Neoplasms

Share to Promoter Regions, Genetic

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Share to Tumor Suppressor Protein p53

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Identifiers

PMID: 34001963
DOI: 10.1038/s41598-021-89906-w
PMCID: PMC8129122

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