Article
Spindle cell carcinoma of head and neck: an immunohistochemical and molecular approach to its pathogenesis.
Journal of clinical pathology - 1 May 2007
Gupta Ruchika, Singh Sompal, Hedau Suresh, Nigam Sonu, Das Bhudev C, Singh Ishwar, Mandal Ashish Kumar
Abstract excerpt
BACKGROUND: Spindle cell carcinoma (SpCC) is a rare microscopic type of cancer of the mouth and oropharynx. Although SpCC is thought to arise from squamous cell carcinoma (SCC), it carries a worse prognosis. AIM: To find out the difference in immunohistochemical expression of cytokeratin, vimentin and smooth-muscle actin, and mutational alterations in the K-ras oncogene between the two tumours, in an attempt to...
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