Article

A high-grade sarcoma with TRIM25::NTRK2 rearrangements in the head and neck: case report

2025-11-20

Abstract excerpt

<title>Abstract</title> <p>NTRK-rearranged spindle cell tumor is a newly identified pathohistological entity defined by molecular features in the 5th edition of the WHO classification of soft tissue and bone tumors. This tumor type most commonly arises in the superficial or deep soft tissues of the extremities, with approximately half of reported cases occurring in children and adolescents. Histologically, it exh...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c2817292-76f4-57be-8c7c-197dcbdddda3
DOI: 10.21203/rs.3.rs-8038082/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A high-grade sarcoma with TRIM25::NTRK2 rearrangements in the head and neck: case reportDOI 10.21203/rs.3.rs-8038082/v1Read

Surgical Resection and Targeted Therapy in a Pediatric NTRK-Rearranged Low- Grade Spindle Cell Sarcoma: A Case ReportSemantic proximity Read

NTRK-Rearranged Spindle Cell Tumor with SPECC1L-NTRK3 Fusion in the Thoracic Spine: A Case ReportSemantic proximity Read

NTRK rearranged spindle cell neoplasm of the uterine cervix: a rare case report and literature reviewSemantic proximity Read

Identification of Dual STRN-NTRK2 Rearrangements in a High Grade Sarcoma, With Good Clinical Response to First-line Larotrectinib TherapySemantic proximity Read

Identification of dual STRN-NTRK2 rearrangements in a high grade sarcoma, with good clinical response to first-line larotrectinib therapySemantic proximity Read

NTRK1-3 Fusions in Sarcomas: Prevalence, Significance, and Clinical Implications – A Systematic ReviewSemantic proximity Read

Rhabdomyosarcoma: Updates on classification and the necessity of molecular testing beyond immunohistochemistry.Semantic proximity Read

Diagnosis and management of tropomyosin receptor kinase (TRK) fusion sarcomas: expert recommendations from the World Sarcoma NetworkSemantic proximity Read

Novel fusion sarcomas including targetable NTRK and ALK.Semantic proximity Read

NTRK-rearranged spindle cell sarcoma of the uterine cervix with a novel NUMA1::NTRK1 fusionSemantic proximity Read

The current landscape of rhabdomyosarcomas: an update.Semantic proximity Read

RREB1::MRTFB fusion-positive extra-glossal mesenchymal neoplasms: A series of five cases expanding their anatomic distribution and highlighting significant morphological and phenotypic diversity.Semantic proximity Read