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Article

Transmission of Multiple HIV-1 Subtype C Transmitted/founder Viruses into the Same Recipients Was not Determined by Modest Phenotypic Differences.

Scientific reports - 2 Dec 2016

Song Hongshuo, Hora Bhavna, Giorgi Elena E, Kumar Amit, Cai Fangping, Bhattacharya Tanmoy, Perelson Alan S, Gao Feng

Abstract excerpt

A severe bottleneck exists during HIV-1 mucosal transmission. However, viral properties that determine HIV-1 transmissibility are not fully elucidated. We identified multiple transmitted/founder (T/F) viruses in six HIV-1-infected subjects by analyzing whole genome sequences. Comparison of biological phenotypes of different T/F viruses from the same individual allowed us to more precisely identify critical...

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Share to Genome, Viral
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Interferon-alpha

Share to Receptors, CCR5

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Source

Open in PubMed Open full text

Identifiers

PMID: 27909304
DOI: 10.1038/srep38130
PMCID: PMC5133561

Genes

CCR5
CCR3
CXCR4
GPR15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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