Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Env sequence determinants in CXCR4-using human immunodeficiency virus type-1 subtype C.

Virology - 25 Nov 2012

Lin Nina H, Becerril Carlos, Giguel Francoise, Novitsky Vladimir, Moyo Sikhulile, Makhema Joseph, Essex Myron, Lockman Shahin, Kuritzkes Daniel R, Sagar Manish

Abstract excerpt

HIV-1 subtype C (HIV-1C) CXCR4-using virus is isolated infrequently and is poorly characterized. Understanding HIV-1C env characteristics has implications for the clinical use of antiretrovirals that target viral entry. A total of 209 env clones derived from 10 samples with mixed CCR5-(R5), CXCR4-using (X4) or dual-tropic HIV-1C were phenotyped for coreceptor usage. Intra-patient X4 and R5 variants generally...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to env Gene Products, Human Immunodeficiency Virus
Share to Genes, env

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HIV Envelope Protein gp120

Share to Host-Pathogen Interactions

Share to Peptide Fragments

Share to Receptors, CCR5

Share to Receptors, CXCR4

Share to Virus Internalization

Source

Open in PubMed Open full text

Identifiers

PMID: 22954962
DOI: 10.1016/j.virol.2012.08.013
PMCID: PMC3616623

Genes

CXCR4
CCR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Env sequence determinants in CXCR4-using human immunodeficiency virus type-1 subtype C.PMID 22954962Read ↗

Genotypic and phenotypic characteristics of CXCR4-using transmitted/founder HIV-1 envelope glycoproteins.Semantic proximity Read ↗

Longitudinal Analysis of CCR5 and CXCR4 Usage in a Cohort of Antiretroviral Therapy-Naïve Subjects with Progressive HIV-1 Subtype C InfectionSemantic proximity Read ↗

CXCR4-using viruses in plasma and peripheral blood mononuclear cells during primary HIV-1 infection and impact on disease progression.Semantic proximity Read ↗

Intrapatient alterations in the human immunodeficiency virus type 1 gp120 V1V2 and V3 regions differentially modulate coreceptor usage, virus inhibition by CC/CXC chemokines, soluble CD4, and the b12 and 2G12 monoclonal antibodies.Semantic proximity Read ↗

CCR5 use by human immunodeficiency virus type 1 is associated closely with the gp120 V3 loop N-linked glycosylation siteSemantic proximity Read ↗

Extreme genetic divergence is required for coreceptor switching in HIV-1 subtype C.Semantic proximity Read ↗

Detection of inferred CCR5- and CXCR4-using HIV-1 variants and evolutionary intermediates using ultra-deep pyrosequencing.Semantic proximity Read ↗

Correlation of coreceptor usage and disease progressionSemantic proximity Read ↗

Variability in the human immunodeficiency virus type 1 gp120 Env protein linked to phenotype-associated changes in the V3 loop.Semantic proximity Read ↗

CCR5 and CXCR4 usage by non-clade B human immunodeficiency virus type 1 primary isolates.Semantic proximity Read ↗

Phenotypic and genotypic comparisons of CCR5- and CXCR4-tropic human immunodeficiency virus type 1 biological clones isolated from subtype C-infected individuals.Semantic proximity Read ↗

Novel envelope determinants for CCR3 use by human immunodeficiency virus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.