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Article

Genetic regulation of insulin resistance surrogate index (TyG) and susceptibility to common diseases based on phenome-wide association study.

Molecular and cellular biochemistry - 1 Jul 2026

Wu Jia-Xin, Bu Ling-Huan, He Pei, Xia Ming-Hui, Bo Lin, Deng Fei-Yan, Lei Shu-Feng

Abstract excerpt

Insulin resistance (IR) is a crucial driver of numerous metabolic and non-metabolic diseases, yet the associations between the triglyceride-glucose (TyG) index-a marker for IR-and a broad spectrum of health conditions remain poorly understood. A large-scale genome-wide association study (GWAS) of triglyceride-glucose (TyG) was performed based on over 320,000 Europeans in the UK Biobank. Then we used Mendelian...

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PMID: 42126675
DOI: 10.1007/s11010-026-05565-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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