Stage-Dependent Genetic Association of the TyG Index with Cardiovascular-Kidney-Metabolic Syndrome Severity: A Genome-Wide Association and Mendelian Randomization Study.

Abstract excerpt

We aimed to determine whether the genetically predicted triglyceride-glucose (TyG) index, a surrogate marker of insulin resistance, is associated with cardiovascular-kidney-metabolic (CKM) stage severity and whether these associations are consistent with a potential causal role of insulin resistance within the CKM staging framework. The associations between the TyG index and CKM stages were assessed among 107,161...

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