Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Immunohistochemical expression of p16(INK4a) is predictive of HR-HPV infection in cervical low-grade lesions.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Mar 2006

Benevolo Maria, Mottolese Marcella, Marandino Ferdinando, Vocaturo Giuseppe, Sindico Roberto, Piperno Giulia, Mariani Luciano, Sperduti Isabella, Canalini Paola, Donnorso Raffaele P, Vocaturo Amina

Abstract excerpt

The p16(INK4a) is a cyclin-dependent kinase inhibitor that decelerates the cell cycle by inactivating the cyclin-dependent kinases involved in the phosphorylation of the retinoblastoma protein (RB). Expression of E6 and E7 oncogenes of high-risk (HR) human papillomavirus (HPV), affecting the RB-p16 pathway, leads to p16 upregulation. Although it is widely reported that p16 is overexpressed in a high percentage of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biopsy
Share to Cervix Uteri

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p16

Share to HeLa Cells

Share to Papillomaviridae

Share to Papillomavirus Infections

Share to Predictive Value of Tests

Share to Uterine Cervical Neoplasms

Source

Identifiers

PMID: 16415792
DOI: 10.1038/modpathol.3800551

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Immunohistochemical expression of p16(INK4a) is predictive of HR-HPV infection in cervical low-grade lesions.PMID 16415792Read ↗

The role of p16 as putative biomarker for cervical neoplasia: A controversial issue?Semantic proximity Read ↗

Biomarkers for cervical cancer screening: the role of p16<sup>INK4a</sup>to highlight transforming HPV infectionsSemantic proximity Read ↗

p16(INK4a) overexpression is not linked to oncogenic human papillomaviruses in patients with high-grade urothelial cancer cells.Semantic proximity Read ↗

Expression Status of p16 Protein Is Associated with Human Papillomavirus Oncogenic Potential in Cervical and Genital LesionsSemantic proximity Read ↗

Expression of p16INK4A in cervical precancerous lesions that is unlikely to be preventable by human papillomavirus vaccines.Semantic proximity Read ↗

Overexpression of p16INK4 is a reliable marker of human papillomavirus–induced oral high-grade squamous dysplasiaSemantic proximity Read ↗

The overexpression of p16 is not a surrogate marker for high-risk human papilloma virus genotypes and predicts clinical outcomes for vulvar cancer.Semantic proximity Read ↗

An upward trend in DNA p16ink4a methylation pattern and high risk HPV infection according to the severity of the cervical lesion.Semantic proximity Read ↗

Frequent HPV-independent p16/INK4A overexpression in head and neck cancer.Semantic proximity Read ↗

Clinical Implications of p16 Evaluation in a Purposively Sampled Cohort of High-Risk Breast Cancer Phenotypes.Semantic proximity Read ↗

Active human papillomavirus involvement in Barrett's dysplasia and oesophageal adenocarcinoma is characterized by wild‐type p53 and aberrations of the retinoblastoma protein pathwaySemantic proximity Read ↗

Immunocytochemical expression of p16INK4a and HPV L1 capsid proteins as predictive markers of the cervical lesions progression risk.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.