Article
Most basal-like breast carcinomas demonstrate the same Rb-/p16+ immunophenotype as the HPV-related poorly differentiated squamous cell carcinomas which they resemble morphologically.
The American journal of surgical pathology - 1 Feb 2009
Subhawong Andrea Proctor, Subhawong Ty, Nassar Hind, Kouprina Nina, Begum Shahnaz, Vang Russell, Westra William H, Argani Pedram
Abstract excerpt
Basal-like carcinomas (BLCs) of the breast share discriminatory morphologic features with poorly differentiated high-risk human papilloma virus (HPV)-related squamous cell carcinomas of the oropharynx, penis, and vulva. Because HPV E7 protein inactivates the retinoblastoma (Rb) protein, diffuse p16 expression is a surrogate marker for these high-risk HPV-related carcinomas. HPV E6 protein also inactivates p53,...
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