Article
P16 and p53 play distinct roles in different subtypes of breast cancer.
PloS one - 1 Jan 2013
Shan Ming, Zhang Xianyu, Liu Xiaolong, Qin Yu, Liu Tong, Liu Yang, Wang Ji, Zhong Zhenbin, Zhang Youxue, Geng Jingshu, Pang Da
Abstract excerpt
Breast cancers are heterogeneous and complex diseases, and subtypes of breast cancers may involve unique molecular mechanisms. The p16(INK4a) and p53 pathways are two of the major pathways involved in control of the cell cycle. They also play key roles in tumorigenesis. However, whether the roles of these pathways differ in the subtypes of breast cancer is unclear. Therefore, p16 and p53 expression were...
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