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Article

RNA Oncoimmune Phenotyping of HPV-Positive p16-Positive Oropharyngeal Squamous Cell Carcinomas by Nodal Status.

JAMA otolaryngology-- head & neck surgery - 1 Nov 2018

Stepp Wesley H, Farquhar Douglas, Sheth Siddharth, Mazul Angela, Mamdani Mohammed, Hackman Trevor G, Hayes D Neil, Zevallos Jose P

Abstract excerpt

Importance: Clinical trials that deintensify treatment for patients with suspected human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) use p16 expression to identify HPV-mediated tumors and guide treatment. While p16 staining has a strong correlation with good outcomes, approximately 12% of p16-positive patients have recurrent disease. Biomarkers that reveal tumor-specific...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29710215
DOI: 10.1001/jamaoto.2018.0602
PMCID: PMC6193859

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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