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Article

Clinicogenetic characteristics and outcomes of children with NUP98-rearranged acute myeloid leukaemia: A single-centre cohort study of 32 cases.

British journal of haematology - 1 Jul 2026

Zhang Zhi-Xiao, Zhang Lin, Lu Ai-Dong, Zhang Le-Ping, Jia Yue-Ping, Zeng Hui-Min

Abstract excerpt

NUP98 rearrangements define a high-risk, genetically heterogeneous subtype of paediatric acute myeloid leukaemia (AML), yet comprehensive clinicogenetic and survival data remain limited. This retrospective, single-centre study of 32 paediatric patients (2017-2025) found a median age of 8.7 years and predominance of the NUP98::NSD1 fusion (68.8%), frequently co-mutated with FLT3-ITD (50%) and WT1 (43.8%). Complete...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42047313
DOI: 10.1111/bjh.70497

Genes

NUP98
WT1
EFS
FLT3
NSD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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