Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Anti-PAD4 antibodies link autoimmunity to PAD4 with CTL-associated rheumatoid arthritis.

Annals of the rheumatic diseases - 1 Aug 2026

Ananth Kusuma, Moosic Katharine B, Gomez-Banuelos Eduardo, Wang Hong, Trejo-Zambrano Isabel, Johnson Ramona, Kirschmann Jessica Marie, Deddens Tess, Elghawy Omar, Shemo Bryna, Robinson William H, Kimpel Donald, Bingham Clifton O, Feith David J, Antiochos Brendan, Andrade Felipe, Loughran Thomas P, Darrah Erika

Abstract excerpt

OBJECTIVES: We aimed to study the serologic, genetic, and immunologic underpinnings associated with cytotoxic T lymphocytes (CTLs) in rheumatoid arthritis (RA), using T-large granular lymphocytic leukaemia with comorbid RA (T-LGLL/RA) as a model of CTL-linked RA. METHODS: We used blood samples and paired clinical data from patients with RA, T-LGLL/RA, T-LGLL and healthy controls. Serological characterisation was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arthritis, Rheumatoid
Share to Autoantibodies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Autoimmunity

Share to Hydrolases

Share to Protein-Arginine Deiminase Type 4

Share to Protein-Arginine Deiminases

Share to STAT3 Transcription Factor

Share to T-Lymphocytes, Cytotoxic

Source

Open in PubMed Open full text

Identifiers

PMID: 42120292
DOI: 10.1016/j.ard.2026.04.006
PMCID: PMC13384482

Genes

PADI4
STAT3
CD69
CD7
KLRG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Anti-PAD4 antibodies link autoimmunity to PAD4 with CTL-associated rheumatoid arthritis.PMID 42120292Read ↗

PAD enzymes in rheumatoid arthritis: pathogenic effectors and autoimmune targets.Semantic proximity Read ↗

Adult-Onset Anti-Citrullinated Peptide Antibody-Negative Destructive Rheumatoid Arthritis Is Characterized by a Disease-Specific CD8+ T Lymphocyte Signature.Semantic proximity Read ↗

From genetics to functional insights into rheumatoid arthritis.Semantic proximity Read ↗

Association of autoimmunity to peptidyl arginine deiminase type 4 with genotype and disease severity in rheumatoid arthritisSemantic proximity Read ↗

Intersection Between Large Granular Lymphocyte Leukemia and Rheumatoid ArthritisSemantic proximity Read ↗

ACPA-negative rheumatoid arthritis: From immune mechanisms to clinical translationSemantic proximity Read ↗

Peptidylarginine Deiminase Autoimmunity and the Development of Anti-Citrullinated Protein Antibody in Rheumatoid Arthritis: The Hapten-Carrier Model.Semantic proximity Read ↗

Molecular Factors in PAD2 (PADI2) and PAD4 (PADI4) Are Associated with Interstitial Lung Disease Susceptibility in Rheumatoid Arthritis Patients.Semantic proximity Read ↗

Activating STAT3 mutations in CD8+ T-cells correlate to serological positivity in rheumatoid arthritis.Semantic proximity Read ↗

Integrated multi‑omics defines immune programmes underlying progression to rheumatoid arthritis in anti-citrullinated protein antibody positive individuals with arthralgia and palindromic rheumatism.Semantic proximity Read ↗

Autoantigen-specific CD8+ T-cell signature in Rheumatoid ArthritisSemantic proximity Read ↗

PADI4 (rs2240340), PDCD1 (rs10204525), and CTLA4 (231775) gene polymorphisms and polyarticular juvenile idiopathic arthritis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.