Article
Peptidylarginine Deiminase Autoimmunity and the Development of Anti-Citrullinated Protein Antibody in Rheumatoid Arthritis: The Hapten-Carrier Model.
Arthritis & rheumatology (Hoboken, N.J.) - 1 Jun 2020
Auger Isabelle, Balandraud Nathalie, Massy Emmanuel, Hemon Marie F, Peen Elisa, Arnoux Fanny, Mariot Charlotte, Martin Marielle, Lafforgue Pierre, Busnel Jean-Marc, Roudier Jean
Abstract excerpt
OBJECTIVE: The presence of autoantibodies to citrullinated proteins (ACPAs) often precedes the development of rheumatoid arthritis (RA). Citrullines are arginine residues that have been modified by peptidylarginine deiminases (PADs). PAD4 is the target of autoantibodies in RA. ACPAs could arise because PAD4 is recognized by T cells, which facilitate the production of autoantibodies to proteins bound by PAD4. We...
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