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Article

Activating STAT3 mutations in CD8+ T-cells correlate to serological positivity in rheumatoid arthritis.

Frontiers in immunology - 1 Jan 2024

Moosic Katharine B, Olson Thomas L, Freijat Mark, Khalique Samara, Hamele Cait E, Shemo Bryna, Boodoo Jesse, Baker William, Khurana Gitanjali, Schmachtenberg Matthew, Duffy Tristin, Ratan Aakrosh, Darrah Erika, Andrade Felipe, Jones Marieke, Olson Kristine C, Feith David J, Kimpel Donald L, Loughran Thomas P

Abstract excerpt

Objectives: Large granular lymphocyte (LGL) leukemia is a rare hematologic malignancy characterized by clonal expansion of cytotoxic T-cells frequent somatic activating STAT3 mutations. Based on the disease overlap between LGL leukemia rheumatoid arthritis (RA)a putative role for CD8+ T-cells in RA we hypothesized that STAT3 mutations may be detected in RA patient CD8+ T-cells correlate with clinical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39497832
DOI: 10.3389/fimmu.2024.1466276
PMCID: PMC11532115

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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