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Article

Genotype-phenotype relationships in butyrylcholinesterase deficiency: a systematic review.

British journal of anaesthesia - 1 Aug 2026

Snak de Souza Cezar D, Ibarra Moreno Carlos A, Riazi Sheila, Hopkins Philip M

Abstract excerpt

BACKGROUND: Butyrylcholinesterase (BChE) deficiency is a recessive condition that can cause prolonged paralysis after suxamethonium or mivacurium. Conventional phenotyping using dibucaine and fluoride inhibition can overlook heterozygous carriers. The aim of this systematic review was to identify studies reporting paired BCHE genotype and biochemical phenotype data to propose a risk-assessment protocol. METHODS:...

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Source

Identifiers

PMID: 42120224
DOI: 10.1016/j.bja.2026.03.056

Genes

BCHE

Variants

Provenance

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