Cholinesterase: phenotyping and genotyping.

doi:10.1258/000456304322879971

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Article

Cholinesterase: phenotyping and genotyping.

Annals of clinical biochemistry - 1 Mar 2004

Goodall Roberta

Abstract excerpt

The plasma enzyme butyrylcholinesterase (BChE) is of clinical interest because of the occurrence of genetic variants with decreased ability to hydrolyse, and therefore inactivate, muscle-relaxant drugs such as suxamethonium. Analysis of BChE involves the determination of both enzyme activity and biochemical phenotypes which are used to determine the risk of so-called 'scoline apnoea'. Problems in analysis arise...

Topics

Acetylcholinesterase
Amino Acid Substitution
Apnea
Butyrylcholinesterase
Cholinesterase Inhibitors
DNA Mutational Analysis
Genetic Variation
Genotype
Humans
Phenotype
Reagent Kits, Diagnostic
Research Design
Sequence Homology, Nucleic Acid
Substrate Specificity
Succinylcholine

Source

Open in PubMed

Identifiers

PMID: 15025799
DOI: 10.1258/000456304322879971

Provenance

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