Article
Cholinesterase: phenotyping and genotyping.
Annals of clinical biochemistry - 1 Mar 2004
Goodall Roberta
Abstract excerpt
The plasma enzyme butyrylcholinesterase (BChE) is of clinical interest because of the occurrence of genetic variants with decreased ability to hydrolyse, and therefore inactivate, muscle-relaxant drugs such as suxamethonium. Analysis of BChE involves the determination of both enzyme activity and biochemical phenotypes which are used to determine the risk of so-called 'scoline apnoea'. Problems in analysis arise...
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