Article
Frequency of butyrylcholinesterase gene mutations in individuals with abnormal inhibition numbers: an Italian-population study.
Pharmacogenetics - 1 May 2003
Lando Giuliana, Mosca Andrea, Bonora Roberto, Azzario Franco, Penco Silvana, Marocchi Alessandro, Panteghini Mauro, Patrosso Maria Cristina
Abstract excerpt
OBJECTIVES: More than 30 genetic variants of serum cholinesterase (butyrylcholinesterase, BChE) have been described. Some of them (the atypical and the fluoride-resistant variants) are well known because carriers are prone to develop prolonged apnea following the administration of the muscle relaxant succinylcholine. Genotype characterization is therefore important in order to prevent such episodes. Genetic...
Topics
- Amino Acid Substitution
- Base Sequence
- Butyrylcholinesterase
- Cholinesterase Inhibitors
- DNA Primers
- Dibucaine
- Fluorides
- Gene Frequency
- Genetic Variation
- Genetics, Behavioral
- Genotype
- Humans
- Inhibition, Psychological
- Italy