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Article

Patients with prolonged effect of succinylcholine or mivacurium had novel mutations in the butyrylcholinesterase gene.

Pharmacogenetics and genomics - 1 Jul 2016

Wichmann Sine, Færk Gitte, Bundgaard Jens R, Gätke Mona R

Abstract excerpt

INTRODUCTION: Mutations in the butyrylcholinesterase enzyme (BChE) can result in prolonged duration of action of the neuromuscular blocking agents, succinylcholine and mivacurium, as BChE hydrolyses these drugs. Hereditary low BChE activity can cause extensively prolonged apnoea during general anaesthesia when these drugs are used. The aim of this study was to describe novel mutations in the butyrylcholinesterase...

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Source

Identifiers

PMID: 27031121
DOI: 10.1097/FPC.0000000000000221

Genes

BCHE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Patients with prolonged effect of succinylcholine or mivacurium had novel mutations in the butyrylcholinesterase gene.PMID 27031121Read ↗

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