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Article

Two novel mutations in the BCHE gene in patients with prolonged duration of action of mivacurium or succinylcholine during anaesthesia.

Pharmacogenetics and genomics - 1 Nov 2007

Gätke Mona R, Bundgaard Jens R, Viby-Mogensen Jørgen

Abstract excerpt

BACKGROUND: Butyrylcholinesterase (BChE) hydrolyses the neuromuscular blocking agents, succinylcholine and mivacurium used during general anaesthesia. Hereditary low BChE activity may result in an extensively prolonged duration of action of these drugs, especially in patients who are homozygous for the atypical or silent variants. We present three novel mutations in the butyrylcholinesterase gene (BCHE)...

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Source

Identifiers

PMID: 18075469
DOI: 10.1097/FPC.0b013e3282f06646

Genes

BCHE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Two novel mutations in the BCHE gene in patients with prolonged duration of action of mivacurium or succinylcholine during anaesthesia.PMID 18075469Read ↗

Patients with prolonged effect of succinylcholine or mivacurium had novel mutations in the butyrylcholinesterase gene.Semantic proximity Read ↗

A novel mutation in the BCHE gene and phenotype identified in a child with low butyrylcholinesterase activity: a case report.Semantic proximity Read ↗

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Rapid and accurate detection of atypical and Kalow variants in the butyrylcholinesterase gene using denaturing high performance liquid chromatography.Semantic proximity Read ↗

Genotype-phenotype relationships in butyrylcholinesterase deficiency: a systematic review.Semantic proximity Read ↗

Molecular basis of succinylcholine sensitivity in a prairie Hutterite kindred and genetic characterization of the region containing the BCHE gene.Semantic proximity Read ↗

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