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Drosophila Models of Alzheimer's Disease: Advances, Limits, and Perspectives

13 Apr 2015

Abstract excerpt

Amyloid-β protein precursor (AβPP) and the microtubule-associated protein tau (MAPT) are the two key players involved in Alzheimer's disease (AD) and are associated with amyloid plaques and neurofibrillary tangles respectively, two key hallmarks of the disease. Besides vertebrate models, Drosophila models have been widely used to understand the complex events leading to AD in relation to aging. Drosophila...

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Alzheimer's disease research and treatments
Cholinesterase and Neurodegenerative Diseases
Genetics, Aging, and Longevity in Model Organisms

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 25697708
DOI: 10.3233/jad-142802

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