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Article

Molecular Genetics of Frontotemporal Dementia Elucidated by Drosophila Models-Defects in Endosomal⁻Lysosomal Pathway.

International journal of molecular sciences - 9 Jun 2018

Vandal Sarah E, Zheng Xiaoyue, Ahmad S Tariq

Abstract excerpt

Frontotemporal dementia (FTD) is the second most common senile neurodegenerative disease. FTD is a heterogeneous disease that can be classified into several subtypes. A mutation in CHMP2B locus (CHMP2Bintron5), which encodes a component of endosomal sorting complex required for transport-III (ESCRT-III), is associated with a rare hereditary subtype of FTD linked to chromosome 3 (FTD-3). ESCRT is involved in...

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PMID: 29890743
DOI: 10.3390/ijms19061714
PMCID: PMC6032313

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