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Article

Motor hypertonia and lack of locomotor coordination in mutant mice lacking DSCAM.

Journal of neurophysiology - 1 Mar 2016

Lemieux Maxime, Laflamme Olivier D, Thiry Louise, Boulanger-Piette Antoine, Frenette Jérôme, Bretzner Frédéric

Abstract excerpt

Down syndrome cell adherence molecule (DSCAM) contributes to the normal establishment and maintenance of neural circuits. Whereas there is abundant literature regarding the role of DSCAM in the neural patterning of the mammalian retina, less is known about motor circuits. Recently, DSCAM mutation has been shown to impair bilateral motor coordination during respiration, thus causing death at birth. DSCAM mutants...

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Source

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Identifiers

PMID: 26683069
DOI: 10.1152/jn.00556.2015
PMCID: PMC4808112

Genes

DSCAM

Provenance

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