Article
Zebrafish dscaml1 Deficiency Impairs Retinal Patterning and Oculomotor Function.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 2 Jan 2020
Ma Manxiu, Ramirez Alexandro D, Wang Tong, Roberts Rachel L, Harmon Katherine E, Schoppik David, Sharma Avirale, Kuang Christopher, Goei Stephanie L, Gagnon James A, Zimmerman Steve, Tsai Shengdar Q, Reyon Deepak, Joung J Keith, Aksay Emre R F, Schier Alexander F, Pan Y Albert
Abstract excerpt
Down syndrome cell adhesion molecules (dscam and dscaml1) are essential regulators of neural circuit assembly, but their roles in vertebrate neural circuit function are still mostly unexplored. We investigated the functional consequences of dscaml1 deficiency in the larval zebrafish (sexually undifferentiated) oculomotor system, where behavior, circuit function, and neuronal activity can be precisely quantified....
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