Germline ATRIP variants and the risk of ovarian cancer.

doi:10.1016/j.gim.2026.102547

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Article

Germline ATRIP variants and the risk of ovarian cancer.

Genetics in medicine : official journal of the American College of Medical Genetics - 1 May 2026

Zamani Neda, Wokołorczyk Dominika, Kluźniak Wojciech, Ogrodniczak Alicja, Jakubowska Anna, Chahal Mehar, Stempa Klaudia, Gliniewicz Katarzyna, Huzarski Tomasz, Rudnicka Helena, Szwiec Marek, Stawicka Malgorzata, Kaznowska Ewa, Kluz Tomasz, Domagała Paweł, Dębniak Tadeusz, McLaughlin John, Lubiński Jan, Gronwald Jacek, Narod Steven A, Kotsopoulos Joanne, Cybulski Cezary, Akbari Mohammad R

Abstract excerpt

PURPOSE: We have previously reported that inherited variants in ATRIP confer a 3-fold risk of developing breast cancer. Here, we investigated potential association between this novel breast cancer susceptibility gene and the risk of ovarian cancer. METHODS: We genotyped the ATRIP c.1152_1155del p.(Gly385Ter) Polish founder variant on germline DNA from 3404 Polish women with ovarian cancer and 9285 healthy...

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PMID: 42118082
DOI: 10.1016/j.gim.2026.102547

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ATRIP

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