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Rare Germline Genetic Variants and the Risks of Epithelial Ovarian Cancer

19 Oct 2020

Abstract excerpt

A family history of ovarian or breast cancer is the strongest risk factor for epithelial ovarian cancer (EOC). Germline deleterious variants in the BRCA1 and BRCA2 genes confer EOC risks by age 80, of 44% and 17% respectively. The mismatch repair genes, particularly MSH2 and MSH6, are also EOC susceptibility genes. Several other DNA repair genes, BRIP1, RAD51C, RAD51D, and PALB2, have been identified as moderate...

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PMID: 33086730
DOI: 10.3390/cancers12103046

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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