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Article

MCM8 and MCM9 Nucleotide Variants in Women with Primary Ovarian Insufficiency

1 Nov 2016

Abstract excerpt

Objective: To assess the frequency of variants, including biallelic pathogenic variants, in minichromosome maintenance 8 (MCM8) and minichromosome maintenance 9 (MCM9), other genes related to MCM8-MCM9, and DNA damage repair (DDR) pathway in participants with primary ovarian insufficiency (POI). Design: MCM8, MCM9, and genes encoding DDR proteins that have been implicated in reproductive aging were sequenced...

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PMID: 27802094
DOI: 10.1210/jc.2016-2565

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