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Article

Genomic instability in ovarian cancer: Through the lens of single nucleotide polymorphisms.

Clinica chimica acta; international journal of clinical chemistry - 15 Jan 2025

Canchi Sistla Harshavardhani, Talluri Srikanth, Rajagopal Taruna, Venkatabalasubramanian Sivaramakrishnan, Rao Dunna Nageswara

Abstract excerpt

Ovarian cancer (OC) is the deadliest gynecological malignancy among all female reproductive cancers. It is characterized by high mortality rate and poor prognosis. Genomic instability caused by mutations, single nucleotide polymorphisms (SNPs), copy number variations (CNVs), microsatellite instability (MSI), and chromosomal instability (CIN) are associated with OC predisposition. SNPs, which are highly prevalent...

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PMID: 39395774
DOI: 10.1016/j.cca.2024.119992

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