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Accurate Prediction for Antibody Resistance of Clinical HIV-1 Isolates

11 Oct 2019

Abstract excerpt

Broadly neutralizing antibodies (bNAbs) targeting the HIV-1 envelope glycoprotein (Env) have promising utility in prevention and treatment of HIV-1 infection, and several are currently undergoing clinical trials. Due to the high sequence diversity and mutation rate of HIV-1, viral isolates are often resistant to specific bNAbs. Currently, resistant isolates are commonly identified by time-consuming and expensive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 31604961
DOI: 10.1038/s41598-019-50635-w

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