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Article

Dual role of glycosylation in resistance to CD4-binding site broadly neutralizing antibodies.

Journal of virology - 19 May 2026

Murphy Teresa, Kelly Meagan, Shimagaki Kai S, DeStefanis Thomas, Galeotos Gabriel, Lee Myungjin, Wei Qing, Novak Jan, Bar Katharine J, Barton John P, Lynch Rebecca M

Abstract excerpt

Broadly neutralizing antibodies (bNAbs) provide a useful tool for HIV cure strategies because of their ability to target conserved regions on the envelope (Env) protein in the context of both virions and infected cells. One of the best-studied bNAbs is the CD4 binding site (CD4bs) antibody VRC01 and others in its class. A major obstacle to effective cure strategies with bNAbs is viral immune escape. A deeper...

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Topics

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Share to Antibodies, Neutralizing
Share to Broadly Neutralizing Antibodies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to CD4 Antigens

Share to CD4-Positive T-Lymphocytes

Share to env Gene Products, Human Immunodeficiency Virus

Share to Glycosylation

Share to HIV Antibodies

Share to Immune Evasion

Source

Open in PubMed Open full text

Identifiers

PMID: 41930967
DOI: 10.1128/jvi.02093-25
PMCID: PMC13185609

Genes

CD4
F3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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