Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Broadly resistant HIV-1 against CD4-binding site neutralizing antibodies

13 Jun 2019

Abstract excerpt

Recently identified broadly neutralizing antibodies (bnAbs) show great potential for clinical interventions against HIV-1 infection. However, resistant strains may impose substantial challenges. Here, we report on the identification and characterization of a panel of HIV-1 strains with broad and potent resistance against a large number of bnAbs, particularly those targeting the CD4-binding site (CD4bs)....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HIV/AIDS drug development and treatment
Share to HIV Research and Treatment
Share to Immune Cell Function and Interaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31194843
DOI: 10.1371/journal.ppat.1007819

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Broadly resistant HIV-1 against CD4-binding site neutralizing antibodiesPMID 31194843Read ↗

Diverse paths to broadly neutralizing antibody escape among HIV-1 strains.Semantic proximity Read ↗

Restriction of HIV-1 Escape by a Highly Broad and Potent Neutralizing Antibody.Semantic proximity Read ↗

Accurate Prediction of Antibody Resistance in Clinical HIV-1 IsolatesSemantic proximity Read ↗

Accurate Prediction for Antibody Resistance of Clinical HIV-1 IsolatesSemantic proximity Read ↗

Profiling a large HIV-1 elite neutralizer cohort reveals remarkable CD4bs bNAb for HIV-1 prevention and therapySemantic proximity Read ↗

A naturally arising broad and potent CD4-binding site antibody with low somatic mutationSemantic proximity Read ↗

A naturally arising broad and potent CD4-binding site antibody with low somatic mutationSemantic proximity Read ↗

Mapping essential somatic hypermutations in a CD4-binding site bNAb informs HIV-1 vaccine designSemantic proximity Read ↗

Characterization of Human Immunodeficiency Virus (HIV-1) Envelope Glycoprotein Variants Selected for Resistance to a CD4-Mimetic Compound.Semantic proximity Read ↗

Dual role of glycosylation in resistance to CD4-binding site broadly neutralizing antibodies.Semantic proximity Read ↗

Broadly Neutralizing Antibodies for HIV EradicationSemantic proximity Read ↗

Structural basis for germline gene usage of a potent class of antibodies targeting the CD4 binding site of HIV-1 gp120Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.