A Functional TNFRSF13B Variant Disrupts B-Cell Enhancer Activity and Increases Susceptibility to EBV-Negative Lymphoma.

doi:10.1016/j.gene.2026.150200

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Article

A Functional TNFRSF13B Variant Disrupts B-Cell Enhancer Activity and Increases Susceptibility to EBV-Negative Lymphoma.

Gene - 20 Aug 2026

Nakano Julia, Viet Nguyen Hoang, Giang Nguyen Hoang Thao, Dac Do Tung, Long Hai Le Ha, Thao Pham Phuong, Nagaya Satomi, Morishita Eriko, Espinoza J Luis

Abstract excerpt

BACKGROUND: Background: The TNFRSF13B gene encodes TACI, a key regulator of B-cell survival and immune homeostasis. While variants in this gene are linked to immunodeficiency, their role in lymphoma development remains unclear. This study investigated whether the TNFRSF13B polymorphism rs4792800 (A>G) influences lymphoma risk. METHODS: We conducted a hospital-based case-control study including 200 histologically...

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Identifiers

PMID: 42114689
DOI: 10.1016/j.gene.2026.150200

Genes

TNFRSF13B
EBF1
PAX5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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