A functional TNFRSF5 gene variant is associated with risk of lymphoma.

doi:10.1182/blood-2007-09-112144

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Article

A functional TNFRSF5 gene variant is associated with risk of lymphoma.

Blood - 15 Apr 2008

Skibola Christine F, Nieters Alexandra, Bracci Paige M, Curry John D, Agana Luz, Skibola Danica R, Hubbard Alan, Becker Nikolaus, Smith Martyn T, Holly Elizabeth A

Abstract excerpt

CD40 and its ligand, CD154, are major costimulatory molecules whose interactions are important in humoral and cellular immunity. We hypothesized that single nucleotide polymorphisms (SNPs) in TNFRSF5 and TNFSF5 encoding the CD40 and CD154 proteins, respectively, influence lymphoma risk, particularly a functional TNFRSF5 SNP (-1C>T, rs1883832) associated with reduced B-cell CD40 expression. TNFRSF5 and TNFSF5 SNPs...

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Identifiers

PMID: 18287517
DOI: 10.1182/blood-2007-09-112144
PMCID: PMC2288730

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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